Publications

* Villanova undergraduate student

** Villanova graduate student

  1. M.M. Karth**, B.J. Baugher**, N. Daly**, M.D. Karth**, S.C. Gironda**, and B.D. Sachs (2019). Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus. Frontiers in Molecular Neuroscience. Dec 11;12:298.
  2. J. Jacobsen, A. Oh, R. Bangle, W. Roberts, E. Royer, S. Windermere, N. Modesto, Z. Yi, R. Vernon, M. Cajina, N. Urs, J. Snyder, P. Nicholls, B. Sachs, and M. Caron, (2019). Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: Mouse proof-of-concept. Neuropsychopharmacology.
  3. Hultman, R., Ulrich, K., Sachs, B.D., Blount, C., Carlson, D.E., Ndubuizu, N., Bagot, R.C., Parise, E.M., Vu, M.T., Gallagher, N.M., Wang, J., Silva AJ, Deisseroth K, Mague SD, Caron MG, Nestler EJ, Carin L, Dzirasa K. (2018) Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability. Cell, Mar 22;173(1):166-180.
  4. B.D. Sachs, H.L. Tran, E. Folse*, and M.G. Caron. (2018). Brain-region-specific molecular responses to maternal separation and social defeat stress in mice. Neuroscience. 373, 122-136. 
  5. B.D. Sachs and K. Dodson** (2017). Serotonin Deficiency and Alcohol Use Disorders. in Addictive Substances and Neurological Disease, Edited by R. Watson and S. Zibadi, Academic Press. 181-189. (Book chapter)
  6. J. P.R. Jacobsen, M. L. Rudder, W. Roberts, E.L. Royer, T.J. Robinson, A. Oh, I. Spasojevic, B.D. Sachs, M.G. Caron, (2016) SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept. Neuropsychopharmacology. Aug;41(9):2324-34.
  7. B. Baeza-Raja, B. D. Sachs, P. Li, F. Christian, E. Vagena, D. Davalos, N. Le Moan, J. K. Ryu, S. L. Sikorski, J. P. Chan, M. Scadeng, S. S. Taylor, M. D. Houslay, G. S. Baillie, A. R. Saltiel, J. M. Olefsky, K. Akassoglou. (2015) Adipocyte-specific p75 neurotrophin receptor regulates lipolysis and energy balance through dissociation of the PKA complex. Cell Reports. Dec 30. pii: S2211-1247(15)01452-7
  8. B. D. Sachs, R. M. Rodriguiz, H.L. Tran, A. Iyer, W. C. Wetsel, M. G. Caron. (2015) Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience. Psychoneuroendocrinology. Jan 6; 53C:69-81.
  9. B.D. Sachs, J. R. Ni and M.G. Caron. (2015) The effects of 5-HT deficiency on responses to psychosocial stress. Proc Natl Acad Sci USA Feb 24;112(8):2557-62.
  10. B. D. Sachs and M. G. Caron. (2014) Chronic fluoxetine increases extra-hippocampal neurogenesis in adult mice. Int. J. Neuropsychopharm. Oct 31;18(4).
  11. J. P.R. Jacobsen, P. Plenge, B. D. Sachs, A. L. Pehrson, M. Cajina, Y. Du, W. Roberts, M. L. Rudder, P. Dalvi, T. J. Robinson, S. P. O’Neill, K. S. Khoo, C. Sanchez, X. Zhang, M. G. Caron. (2014) The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse. Psychopharmacology. Dec; 23 1(23):4527-40
  12. B.D. Sachs, J. Ni and M.G. Caron. (2014) Sex differences in response to chronic mild stress and congenital 5-HT deficiency. Psychoneuroendocrinology. Feb; 40:123-9.
  13. B.D. Sachs, A.A. Salahi, and M.G. Caron. (2014). Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice. Neuropharmacology. February, 77:177-84.
  14. B.D. Sachs, J.P.R. Jacobsen, T.L. Thomas, W.B. Siesser, W.L. Roberts and M.G. Caron. (2013) Brain serotonin deficiency impairs behavioral and neurogenic responses to chronic fluoxetine administration. Transl. Psychiatry. Aug 13;3:e291, PMC3756292.
  15. B.D. Sachs, R.M. Rodriguiz, W.B. Siesser, A. Kenan, E. Royer, J. P.R. Jacobsen, W.C. Wetsel and M.G. Caron. (2013) The effects of brain serotonin deficiency on behavioral disinhibition and anxiety-like behavior following mild early life stress. Int. J. Neuropsychopharm. May 14:1-14. PMC in process.
  16. K. Dzirasa, S. Kumar, B. Sachs, M. G. Caron, M. A. L. Nicolelis (2013). Cortical-amygdalar circuit dysfunction in a genetic mouse model of depression. J Neurosci. Mar 6;33(10):4505-13. PMC3633471.
  17. M. Hara, B.D. Sachs, M.G. Caron, R.J. Lefkowitz (2013). Pharmacological blockade of a β2AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle. Jan 15;12(2):219-24. PMC3575451.
  18. W.B. Siesser, B.D. Sachs, A.J. Ramsey, T.D. Sotnikova, J.M. Beaulieu, X. Zhang, M.G. Caron, R.R. Gainetdinov. (2013). Chronic antidepressant treatment exacerbates serotonin deficiency in humanized tph2 mutant mice. ACS Chem. Neuroscience. Jan 16;4(1):84-8. PMC3547473.
  19. B. Baeza-Raja, P. Li, N. Le Moan, B.D. Sachs, C. Schachtrup, D. Davalos, E. Vagena, D. Bridges, C. Kim, A. Saltiel, J. Olefsky, K. Akassoglou. 2012. The p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci USA, 109(15):5838-43.
  20. J.P. Jacobsen, W.B. Siesser, B.D. Sachs, S. Peterson, M.J. Cools, V. Setola, J.H. Folgering, G. Flik, M.G. Caron. 2012. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Mol Psychiatry. May 3.
  21. M. Xu, C. V. Remillard, B. D. Sachs, A. Makino, O. Platoshyn, W. H. Dillmann, K. Akassoglou, and J. X.-J. Yuan, 2008. p75 Neurotrophin Receptor Regulates Agonist-induced Pulmonary Vasoconstriction. Am J Physiol Heart Circ Physiol, 295(4):H1529-38.
  22. B.D. Sachs, K. Akassoglou. Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors. 2007. Biochem Soc Trans, 35:1273-1277. Review.
  23. C. Schachtrup, P. Lu, L.L. Jones, J.K Lee, J. Lu, B.D. Sachs, B. Zheng, K. Akassoglou. 2007. Fibrinogen inhibits neurite outgrowth via beta3 integrin-mediated phosphorylation of the EGF receptor.  Proc Natl Acad Sci USA, 104:11814-11819.
  24. B.D. Sachs, G. S. Baillie, J. R. McCall, M. A. Passino, C. Schachtrup, D. A. Wallace, A. J. Dunlop, K. F. MacKenzie, E. Klussmann, M. J. Lynch, S. L. Sikorski, T. Nuriel, I. Tsigelny, J. Zhang, M. D. Houslay, M. V. Chao, and K. Akassoglou. 2007. p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.  J Cell Biol, 177:1119–1132.
  25. R.A. Adams, M. Passino, B.D. Sachs, T. Nuriel, K. Akassoglou. 2004. Fibrin mechanisms and functions in nervous system pathology.  Molecular Interventions, 4:163-76. Review.
  26. B.E. Thompson, B.D. Sachs, Kathleen M. Kantak, J.A. Cherry. The Type IV Phosphodiesterase Inhibitor Rolipram Interferes With Drug-Induced Conditioned Place Preference but not Immediate Early Gene Induction in Mice. Eur J Neurosci, 19:2561-8.
  27. D.A. Gold, S.H. Baek, N.J. Schork, D.W. Rose, D.D. Larsen, B.D. Sachs, M.G. Rosenfeld, B.A. Hamilton, 2003. RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 40:1119-1131.