Publications

* Villanova undergraduate student

** Villanova graduate student

  1. Hultman, R., Ulrich, K., Sachs, B.D., Blount, C., Carlson, D.E., Ndubuizu, N., Bagot, R.C., Parise, E.M., Vu, M.T., Gallagher, N.M., Wang, J., Silva AJ, Deisseroth K, Mague SD, Caron MG, Nestler EJ, Carin L, Dzirasa K. (2018) Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability. Cell, Mar 22;173(1):166-180.
  2. B.D. Sachs, H.L. Tran, E. Folse*, and M.G. Caron. (2018). Brain-region-specific molecular responses to maternal separation and social defeat stress in mice. Neuroscience. 373, 122-136. 
  3. B.D. Sachs and K. Dodson** (2017). Serotonin Deficiency and Alcohol Use Disorders. in Addictive Substances and Neurological Disease, Edited by R. Watson and S. Zibadi, Academic Press. 181-189.
  4. J. P.R. Jacobsen, M. L. Rudder, W. Roberts, E.L. Royer, T.J. Robinson, A. Oh, I. Spasojevic, B.D. Sachs, M.G. Caron, (2016) SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept. Neuropsychopharmacology. Aug;41(9):2324-34.
  5. B. Baeza-Raja, B. D. Sachs, P. Li, F. Christian, E. Vagena, D. Davalos, N. Le Moan, J. K. Ryu, S. L. Sikorski, J. P. Chan, M. Scadeng, S. S. Taylor, M. D. Houslay, G. S. Baillie, A. R. Saltiel, J. M. Olefsky, K. Akassoglou. (2015) Adipocyte-specific p75 neurotrophin receptor regulates lipolysis and energy balance through dissociation of the PKA complex. Cell Reports. Dec 30. pii: S2211-1247(15)01452-7
  6. B. D. Sachs, R. M. Rodriguiz, H.L. Tran, A. Iyer, W. C. Wetsel, M. G. Caron. (2015) Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience. Psychoneuroendocrinology. Jan 6; 53C:69-81.
  7. B.D. Sachs, J. R. Ni and M.G. Caron. (2015) The effects of 5-HT deficiency on responses to psychosocial stress. Proc Natl Acad Sci USA Feb 24;112(8):2557-62.
  8. B. D. Sachs and M. G. Caron. (2014) Chronic fluoxetine increases extra-hippocampal neurogenesis in adult mice. Int. J. Neuropsychopharm. Oct 31;18(4).
  9. J. P.R. Jacobsen, P. Plenge, B. D. Sachs, A. L. Pehrson, M. Cajina, Y. Du, W. Roberts, M. L. Rudder, P. Dalvi, T. J. Robinson, S. P. O’Neill, K. S. Khoo, C. Sanchez, X. Zhang, M. G. Caron. (2014) The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse. Psychopharmacology. Dec; 23 1(23):4527-40
  10. B.D. Sachs, J. Ni and M.G. Caron. (2014) Sex differences in response to chronic mild stress and congenital 5-HT deficiency. Psychoneuroendocrinology. Feb; 40:123-9.
  11. B.D. Sachs, A.A. Salahi, and M.G. Caron. (2014). Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice. Neuropharmacology. February, 77:177-84.
  12. B.D. Sachs, J.P.R. Jacobsen, T.L. Thomas, W.B. Siesser, W.L. Roberts and M.G. Caron. (2013) Brain serotonin deficiency impairs behavioral and neurogenic responses to chronic fluoxetine administration. Transl. Psychiatry. Aug 13;3:e291, PMC3756292.
  13. B.D. Sachs, R.M. Rodriguiz, W.B. Siesser, A. Kenan, E. Royer, J. P.R. Jacobsen, W.C. Wetsel and M.G. Caron. (2013) The effects of brain serotonin deficiency on behavioral disinhibition and anxiety-like behavior following mild early life stress. Int. J. Neuropsychopharm. May 14:1-14. PMC in process.
  14. K. Dzirasa, S. Kumar, B. Sachs, M. G. Caron, M. A. L. Nicolelis (2013). Cortical-amygdalar circuit dysfunction in a genetic mouse model of depression. J Neurosci. Mar 6;33(10):4505-13. PMC3633471.
  15. M. Hara, B.D. Sachs, M.G. Caron, R.J. Lefkowitz (2013). Pharmacological blockade of a β2AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle. Jan 15;12(2):219-24. PMC3575451.
  16. W.B. Siesser, B.D. Sachs, A.J. Ramsey, T.D. Sotnikova, J.M. Beaulieu, X. Zhang, M.G. Caron, R.R. Gainetdinov. (2013). Chronic antidepressant treatment exacerbates serotonin deficiency in humanized tph2 mutant mice. ACS Chem. Neuroscience. Jan 16;4(1):84-8. PMC3547473.
  17. B. Baeza-Raja, P. Li, N. Le Moan, B.D. Sachs, C. Schachtrup, D. Davalos, E. Vagena, D. Bridges, C. Kim, A. Saltiel, J. Olefsky, K. Akassoglou. 2012. The p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci USA, 109(15):5838-43.
  18. J.P. Jacobsen, W.B. Siesser, B.D. Sachs, S. Peterson, M.J. Cools, V. Setola, J.H. Folgering, G. Flik, M.G. Caron. 2012. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Mol Psychiatry. May 3.
  19. M. Xu, C. V. Remillard, B. D. Sachs, A. Makino, O. Platoshyn, W. H. Dillmann, K. Akassoglou, and J. X.-J. Yuan, 2008. p75 Neurotrophin Receptor Regulates Agonist-induced Pulmonary Vasoconstriction. Am J Physiol Heart Circ Physiol, 295(4):H1529-38.
  20. B.D. Sachs, K. Akassoglou. Regulation of cAMP by the p75 neurotrophin receptor: insight into drug design of selective phosphodiesterase inhibitors. 2007. Biochem Soc Trans, 35:1273-1277. Review.
  21. C. Schachtrup, P. Lu, L.L. Jones, J.K Lee, J. Lu, B.D. Sachs, B. Zheng, K. Akassoglou. 2007. Fibrinogen inhibits neurite outgrowth via beta3 integrin-mediated phosphorylation of the EGF receptor.  Proc Natl Acad Sci USA, 104:11814-11819.
  22. B.D. Sachs, G. S. Baillie, J. R. McCall, M. A. Passino, C. Schachtrup, D. A. Wallace, A. J. Dunlop, K. F. MacKenzie, E. Klussmann, M. J. Lynch, S. L. Sikorski, T. Nuriel, I. Tsigelny, J. Zhang, M. D. Houslay, M. V. Chao, and K. Akassoglou. 2007. p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.  J Cell Biol, 177:1119–1132.
  23. R.A. Adams, M. Passino, B.D. Sachs, T. Nuriel, K. Akassoglou. 2004. Fibrin mechanisms and functions in nervous system pathology.  Molecular Interventions, 4:163-76. Review.
  24. B.E. Thompson, B.D. Sachs, Kathleen M. Kantak, J.A. Cherry. The Type IV Phosphodiesterase Inhibitor Rolipram Interferes With Drug-Induced Conditioned Place Preference but not Immediate Early Gene Induction in Mice. Eur J Neurosci, 19:2561-8.
  25. D.A. Gold, S.H. Baek, N.J. Schork, D.W. Rose, D.D. Larsen, B.D. Sachs, M.G. Rosenfeld, B.A. Hamilton, 2003. RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 40:1119-1131.